Le Roch LabEpigenetics & Chromatin
Epigenetics & Chromatin2026
Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection
Ciampossin L, Ulu A, Lenz T, Li Z, Abel S, Srivastava S, White M, Wilson E, Le Roch KG
Publications
The written record.
More than 140 peer-reviewed papers, cited over 26,000 times.
eLife2026
Epigenetics and chromatin structure regulate var2csa expression and the placental-binding phenotype in Plasmodium falciparum
Lenz T, Sirel M, Hoppe H, Shafeeq S, Le Roch KG, Ribacke U
eLife2025
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
Maher SP, Bakowski MA, Vantaux A, Flannery EL, Andolina C, Gupta M, Antonova-Koch Y, Argomaniz M, Cabrera-Mora M, Campo B, Chao AT, Chatterjee AK, Cheng WT, Chuenchob V, Cooper CA, Cottier K, Galinski MR, Harupa-Chung A, Ji H, Joseph SB, Lenz T, Lonardi S, Matheson J, Mikolajczak SA, Moeller T, Orban A, Padín-Irizarry V, Pan K, Péneau J, Prudhomme J, Roesch C, Ruberto A, Sabnis SS, Saney CL, Sattabongkot J, Sereshki S, Suriyakan S, Ubalee R, Wang Y, Wasisakun P, Yin J, Popovici J, McNamara CW, Joyner C, Nosten FH, Witkowski B, Le Roch KG, Kyle DE
Cell Reports2025
RAP proteins regulate apicoplast noncoding RNA processing in Plasmodium falciparum
Hollin T, Chahine Z, Abel S, Banks C, Pasaje CFA, Lenz T, Prudhomme J, Ybanez CM, Abbaszadeh AS, Niles JC, Florens L, Le Roch KG
Nature Communications2025
The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death
Grilo Ruivo MT, Shin JH, Lenz T, Matsuno SY, Yanes KO, Graindorge A, Hamie M, Berry-Sterkers L, Gissot M, El Hajj H, Le Roch KG, Lodoen MB, Lebrun M, Penarete-Vargas DM
eLife2024
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
Chahine ZM, Gupta M, Lenz T, Hollin T, Abel S, Banks C, Saraf A, Prudhomme J, Bhanvadia S, Florens LA, Le Roch KG
Science2024
A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria
Chahine Z, Abel S, Hollin T, Barnes GL, Chung JH, Daub ME, Renard I, Choi JY, Vydyam P, Pal A, Alba-Argomaniz M, Banks CAS, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas MC, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner CJ, Bei AK, Florens L, Ben Mamoun C, Vanderwal CD, Le Roch KG
Nature Communications2024
Proteome-Wide Identification of RNA-dependent proteins and an emerging role for RNAs in Plasmodium falciparum protein complexes
Hollin T, Abel S, Banks C, Hristov B, Prudhomme J, Hales K, Florens L, Stafford Noble W, Le Roch KG
Nature Communications2023
Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum
Batugedara G, Lu XM, Hristov B, Abel S, Chahine Z, Hollin T, Williams D, Wang T, Cort A, Lenz T, Thompson TA, Prudhomme J, Tripathi AK, Xu G, Cudini J, Dogga S, Lawniczak M, Noble WS, Sinnis P, Le Roch KG
Scientific Reports
Scientific Reports2023
Small RNA sequencing of field Culex mosquitoes identifies patterns of viral infection and the mosquito immune response
Abel SM, Hong Z, Williams D, Ireri S, Brown MQ, Su T, Hung KY, Henke JA, Barton JP, Le Roch KG
Nature Microbiology2023
Babesia duncani multi-omics identifies virulence factors and drug targets
Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu XM, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez LM, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb OS, Le Roch KG, Ben Mamoun C
Journal of the American Chemical Society2023
An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure
Dwulet NC, Chahine Z, Le Roch KG, Vanderwal CD
Nature Communications2022
Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum
Hollin T, Abel S, Falla A, Pasaje CFA, Bhatia A, Hur M, Kirkwood JS, Saraf A, Prudhomme J, De Souza A, Florens L, Niles JC, Le Roch KG
Nucleic Acids Research2020
Measuring significant changes in chromatin conformation with ACCOST
Cook KB, Hristov BH, Le Roch KG, Vert JP, Noble WS
PLoS Computational Biology
PLoS Computational Biology2019
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features
Read DF, Cook KB, Lu YY, Le Roch KG, Noble WS
- Citations
- 26,000+Citations
- h-index
- 56h-index
- i10-index
- 122i10-index
140 peer-reviewed articles14 book chapters3 US patents
Metrics via Google Scholar · updated August 2026
Methods in Molecular Biology
Methods in Molecular Biology2021
Chromosomes Conformation Capture Coupled with Next-Generation Sequencing (Hi-C) in Plasmodium falciparum
Gupta MK, Lenz T, Le Roch KG
Methods in Molecular Biology
Methods in Molecular Biology2021
Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq
Hollin T, Abel S, Le Roch KG
Methods in Molecular Biology
Methods in Molecular Biology
Methods in Molecular Biology2012
Strand-specific RNA-seq applied to malaria samples
Ponts N, Chung DW, Le Roch KG