Le Roch LabEpigenetics & Chromatin
Epigenetics & Chromatin2026
Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection
Ciampossin L, Ulu A, Lenz T, Li Z, Abel S, Srivastava S, White M, Wilson E, Le Roch KG
Publications
The written record.
More than 140 peer-reviewed papers, cited over 26,000 times.
eLife2026
Epigenetics and chromatin structure regulate var2csa expression and the placental-binding phenotype in Plasmodium falciparum
Lenz T, Sirel M, Hoppe H, Shafeeq S, Le Roch KG, Ribacke U
eLife2025
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
Maher SP, Bakowski MA, Vantaux A, Flannery EL, Andolina C, Gupta M, Antonova-Koch Y, Argomaniz M, Cabrera-Mora M, Campo B, Chao AT, Chatterjee AK, Cheng WT, Chuenchob V, Cooper CA, Cottier K, Galinski MR, Harupa-Chung A, Ji H, Joseph SB, Lenz T, Lonardi S, Matheson J, Mikolajczak SA, Moeller T, Orban A, Padín-Irizarry V, Pan K, Péneau J, Prudhomme J, Roesch C, Ruberto A, Sabnis SS, Saney CL, Sattabongkot J, Sereshki S, Suriyakan S, Ubalee R, Wang Y, Wasisakun P, Yin J, Popovici J, McNamara CW, Joyner C, Nosten FH, Witkowski B, Le Roch KG, Kyle DE
eLife2024
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
Chahine ZM, Gupta M, Lenz T, Hollin T, Abel S, Banks C, Saraf A, Prudhomme J, Bhanvadia S, Florens LA, Le Roch KG
Nature Communications2023
Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum
Batugedara G, Lu XM, Hristov B, Abel S, Chahine Z, Hollin T, Williams D, Wang T, Cort A, Lenz T, Thompson TA, Prudhomme J, Tripathi AK, Xu G, Cudini J, Dogga S, Lawniczak M, Noble WS, Sinnis P, Le Roch KG
Nature Microbiology2023
Babesia duncani multi-omics identifies virulence factors and drug targets
Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu XM, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez LM, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb OS, Le Roch KG, Ben Mamoun C
Nucleic Acids Research2020
Measuring significant changes in chromatin conformation with ACCOST
Cook KB, Hristov BH, Le Roch KG, Vert JP, Noble WS
PLoS Computational Biology
PLoS Computational Biology2019
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features
Read DF, Cook KB, Lu YY, Le Roch KG, Noble WS
PNAS2019
Comparative 3D genome organization in apicomplexan parasites
Bunnik EM, Venkat A, Shao J, McGovern KE, Batugedara G, Worth D, Prudhomme J, Lapp SA, Andolina C, Ross LS, Lawres L, Brady D, Sinnis P, Nosten F, Fidock DA, Wilson EH, Tewari R, Galinski MR, Ben Mamoun C, Ay F, Le Roch KG
Nature Communications2018
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
Bunnik EM, Cook KB, Varoquaux N, Batugedara G, Prudhomme J, Cort A, Shi L, Andolina C, Ross LS, Brady D, Fidock DA, Nosten F, Tewari R, Sinnis P, Ay F, Vert JP, Noble WS, Le Roch KG
Nucleic Acids Research2017
Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum
Lu XM, Batugedara G, Lee M, Prudhomme J, Bunnik EM, Le Roch KG
Journal of Proteome Research
Journal of Proteome Research2016
Dynamic and Combinatorial Landscape of Histone Modifications during the Intraerythrocytic Developmental Cycle of the Malaria Parasite
Saraf A, Cervantes S, Bunnik EM, Ponts N, Sardiu ME, Chung DWD, Prudhomme J, Varberg JM, Wen Z, Washburn MP, Florens L, Le Roch KG
BMC Genomics
BMC Genomics2015
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum
Lu XM, Bunnik EM, Pokhriyal N, Nasseri S, Lonardi S, Le Roch KG
BMC Bioinformatics2014
PuFFIN - a parameter-free method to build nucleosome maps from paired-end reads
Polishko A, Bunnik EM, Le Roch KG, Lonardi S
Genome Research2014
Three-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene expression
Ay F, Bunnik EM, Varoquaux N, Bol SM, Prudhomme J, Vert JP, Noble WS, Le Roch KG
- Citations
- 26,000+Citations
- h-index
- 56h-index
- i10-index
- 122i10-index
140 peer-reviewed articles14 book chapters3 US patents
Metrics via Google Scholar · updated August 2026
Methods in Molecular Biology
Methods in Molecular Biology2021
Chromosomes Conformation Capture Coupled with Next-Generation Sequencing (Hi-C) in Plasmodium falciparum
Gupta MK, Lenz T, Le Roch KG
Methods in Molecular Biology
Methods in Molecular Biology2021
Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq
Hollin T, Abel S, Le Roch KG
Methods in Molecular Biology
Methods in Molecular Biology
Methods in Molecular Biology2012
Strand-specific RNA-seq applied to malaria samples
Ponts N, Chung DW, Le Roch KG